منابع مشابه
Double-punching PMBL
Success stories in looking for effective strategies against cancer often have their roots in pathology. In case of primary mediastinal B-cell lymphoma (PMBL), this was likely the recognition as a distinct subtype of diffuse large B-cell lymphoma (DLBCL) in the early 80s [1, 2]. Initially a controversial entity, over the last 30 years, it has become clear that PMBL differs in pathogenesis, clini...
متن کاملTargeting STAT6 in PMBL
Primary Mediastinal B-cell Lymphoma (PMBL) is a specific subtype of B-cell lymphoma which shares some phenotypic and genotypic features with diffuse large B-cell lymphoma (DLBCL) and with classical Hodgkin’s lymphoma (HL). The genomic landscape of PMBL has not been fully elucidated, but has revealed the recurrent alteration of genes involved in JAK-STAT signaling and in immune surveillance [1]....
متن کاملTargeting the intratumor heterogeneity in PMBL
Primary mediastinal B cell lymphoma (PMBL) affects predominantly young females and belongs to the most curable lymphoma subtypes. Nevertheless, treatment-related troubles were recognized: (1) late complications due to chemotherapy and radiation; (2) treatment failure during salvage therapy of relapsed patients. Therefore, further investigations of molecular mechanisms of PMBL oncogenesis are wa...
متن کاملMeniscal shear stress for punching.
AIM Experimental determination of the shear stress for punching meniscal tissue. METHODS Meniscectomy (surgical treatment of a lesion of one of the menisci) is the most frequently performed arthroscopic procedure. The performance of a meniscectomy is not optimal with the currently available instruments. To design new instruments, the punching force of meniscal tissue is an important parameter...
متن کاملStrength of Footing with Punching Shear Preventers
The punching shear failure often governs the strength of the footing-to-column connection. The punching shear failure is an undesirable failure mode, since it results in a brittle failure of the footing. In this study, a new method to increase the strength and ductility of the footing was proposed by inserting the punching shear preventers (PSPs) into the footing. The validation and effectivene...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2014
ISSN: 1949-2553
DOI: 10.18632/oncotarget.2827